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- TIE2 activation by antibody-clustered endogenous angiopoietin-2 prevents capillary loss and fibrosis in experimental kidney disease.
Pietilä R, Marks-Hultström AM, He L, Nanavazadeh S, Quaggin SE, Betsholtz C, Jeansson M.J Clin Invest. 2025 Sep 15:e190286. doi: 10.1172/JCI190286. PMID: 40952790
- A comprehensive molecular atlas of the mesenchymal cell types in the mouse liver.
Pietilä R, Genové G, Mocci G, Miao Y, Liu J, Leptidis S, Del Gaudio F, Uhrbom M, Vázquez-Liébanas E, Gustafsson S, Buyandelger B, Raschperger E, Björkegren JLM, Hansson EM, Gaengel K, Mäe MA, Jeansson M, Vanlandewijck M, He L, Strell C, Peng XR, Lendahl U, Betsholtz C, Muhl L. EMBO Rep. 2025 Sep 15. doi: 10.1038/s44319-025-00580-9. PMID: 40954217
- Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium.
Schoofs H, Daubel N, Schnabellehner S, Grönloh MLB, Palacios Martínez S, Halme A, Marks AM, Jeansson M, Barcos S, Brakebusch C, Benedito R, Engelhardt B, Vestweber D, Gaengel K, Linsenmeier F, Schürmann S, Saharinen P, van Buul JD, Friedrich O, Smith RS, Majda M, Mäkinen T. Nature. 2025 May;641(8062):465-475. doi: 10.1038/s41586-025-08724-6. PMID: 40108458
- Different gene expression patterns between mouse and human brain pericytes revealed by single-cell/nucleus RNA sequencing.
Miao Y, Li W, Jeansson M, Mäe MA, Muhl L, He L. Vascul Pharmacol. 2024 Dec;157:107434. doi: 10.1016/j.vph.2024.107434. Epub 2024 Oct 17.PMID: 39423955
- Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts.
Uhrbom M, Muhl L, Genové G, Liu J, Palmgren H, Alexandersson I, Karlsson F, Zhou AX, Lunnerdal S, Gustafsson S, Buyandelger B, Petkevicius K, Ahlstedt I, Karlsson D, Aasehaug L, He L, Jeansson M, Betsholtz C, Peng XR. Nat Commun. 2024 Sep 2;15(1):7643. doi: 10.1038/s41467-024-51867-9. PMID: 39223126
- Renal Endothelial Single-Cell Transcriptomics Reveals Spatiotemporal Regulation and Divergent Roles of Differential Gene Transcription and Alternative Splicing in Murine Diabetic Nephropathy.
Zhou AX$, Jeansson M$, He L, Wigge L, Tonelius P, Tati R, Cederblad L, Muhl L, Uhrbom M, Liu J, Björnson Granqvist A, Lerman LO, Betsholtz C, Hansen PBL. Int J Mol Sci. 2024 Apr 13;25(8):4320. doi: 10.3390/ijms25084320. PMID: 38673910 $equal contribution
- Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation-A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients.
Hultström M, Fromell K, Larsson A, Persson B, Nilsson B, Quaggin SE, Betsholtz C, Frithiof R, Lipcsey M, Jeansson M. Biomedicines. 2022 Jun 6;10(6):1333. doi: 10.3390/biomedicines10061333.PMID: 35740360
- Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes.
He B, Chen P, Zambrano S, Dabaghie D, Hu Y, Möller-Hackbarth K, Unnersjö-Jess D, Korkut GG, Charrin E, Jeansson M, Bintanel-Morcillo M, Witasp A, Wennberg L, Wernerson A, Schermer B, Benzing T, Ernfors P, Betsholtz C, Lal M, Sandberg R, Patrakka J. Nat Commun. 2021 Apr 9;12(1):2141. doi: 10.1038/s41467-021-22331-9.PMID: 33837218
- Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss.
Mäe MA, He L, Nordling S, Vazquez-Liebanas E, Nahar K, Jung B, Li X, Tan BC, Chin Foo J, Cazenave-Gassiot A, Wenk MR, Zarb Y, Lavina B, Quaggin SE, Jeansson M, Gu C, Silver DL, Vanlandewijck M, Butcher EC, Keller A, Betsholtz C. Circ Res. 2021 Feb 19;128(4):e46-e62. doi: 10.1161/CIRCRESAHA.120.317473. Epub 2020 Dec 30. PMID: 33375813
- Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice.
Loganathan K, Salem Said E, Winterrowd E, Orebrand M, He L, Vanlandewijck M, Betsholtz C, Quaggin SE, Jeansson M. PLoS One. 2018 Jan 2;13(1):e0189433. doi: 10.1371/journal.pone.0189433. PMID: 29293543
- Angiopoietin-1 deficiency increases tumor metastasis in mice.
Michael IP, Orebrand M, Lima M, Pereira B, Volpert O, Quaggin SE, Jeansson M.BMC Cancer. 2017 Aug 11;17(1):539. doi: 10.1186/s12885-017-3531-y. PMID: 28800750
- Antitumoral effect and reduced systemic toxicity in mice after intra-tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel.
Grudén S, Sandelin M, Rasanen V, Micke P, Hedeland M, Axén N, Jeansson M.Eur J Pharm Biopharm. 2017 May;114:186-193. doi: 10.1016/j.ejpb.2017.01.018. PMID: 28161551
- Vascular Growth Factors and Glomerular Disease.
Bartlett CS, Jeansson M, Quaggin SE. Annu Rev Physiol. 2016;78:437-61. doi: 10.1146/annurev-physiol-021115-105412.PMID: 26863327 Review.
- A lymphatic defect causes ocular hypertension and glaucoma in mice.
Thomson BR, Heinen S, Jeansson M, Ghosh AK, Fatima A, Sung HK, Onay T, Chen H, Yamaguchi S, Economides AN, Flenniken A, Gale NW, Hong YK, Fawzi A, Liu X, Kume T, Quaggin SE. J Clin Invest. 2014 Oct;124(10):4320-4. doi: 10.1172/JCI77162. PMID: 25202984
- Loss of the podocyte-expressed transcription factor Tcf21/Pod1 results in podocyte differentiation defects and FSGS.
Maezawa Y, Onay T, Scott RP, Keir LS, Dimke H, Li C, Eremina V, Maezawa Y, Jeansson M, Shan J, Binnie M, Lewin M, Ghosh A, Miner JH, Vainio SJ, Quaggin SE. J Am Soc Nephrol. 2014 Nov;25(11):2459-70. doi: 10.1681/ASN.2013121307. PMID: 24904088
- Insulin-like growth factor-II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse.
Hale LJ, Welsh GI, Perks CM, Hurcombe JA, Moore S, Hers I, Saleem MA, Mathieson PW, Murphy AJ, Jeansson M, Holly JM, Hardouin SN, Coward RJ. J Pathol. 2013 May;230(1):95-106. doi: 10.1002/path.4165. PMID: 23299523
- The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier.
Bisson N, Ruston J, Jeansson M, Vanderlaan R, Hardy WR, Du J, Hussein SM, Coward RJ, Quaggin SE, Pawson T. PLoS One. 2012;7(11):e50996. doi: 10.1371/journal.pone.0050996. PMID: 23226445
- Vegfa protects the glomerular microvasculature in diabetes.
Sivaskandarajah GA, Jeansson M, Maezawa Y, Eremina V, Baelde HJ, Quaggin SE. Diabetes. 2012 Nov;61(11):2958-66. doi: 10.2337/db11-1655. PMID: 23093658
- Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function.
Jin J, Sison K, Li C, Tian R, Wnuk M, Sung HK, Jeansson M, Zhang C, Tucholska M, Jones N, Kerjaschki D, Shibuya M, Fantus IG, Nagy A, Gerber HP, Ferrara N, Pawson T, Quaggin SE. Cell. 2012 Oct 12;151(2):384-99. doi: 10.1016/j.cell.2012.08.037. PMID: 23063127
- Regulation of hypoxia-inducible factor 2-a is essential for integrity of the glomerular barrier.
Ding M, Coward RJ, Jeansson M, Kim W, Quaggin SE. Am J Physiol Renal Physiol. 2013 Jan 1;304(1):F120-6. doi: 10.1152/ajprenal.00416.2012. Epub 2012 Oct 10. PMID: 23054256
- Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation.
Cai Q, Brissova M, Reinert RB, Pan FC, Brahmachary P, Jeansson M, Shostak A, Radhika A, Poffenberger G, Quaggin SE, Jerome WG, Dumont DJ, Powers AC.Dev Biol. 2012 Jul 1;367(1):40-54. doi: 10.1016/j.ydbio.2012.04.022. Epub 2012 Apr 24.PMID: 22546694
- Angiopoietin-1 is essential in mouse vasculature during development and in response to injury.
Jeansson M, Gawlik A, Anderson G, Li C, Kerjaschki D, Henkelman M, Quaggin SE. J Clin Invest. 2011 Jun;121(6):2278-89. doi: 10.1172/JCI46322. PMID: 21606590
- New insights into the pathogenesis of cellular crescents.
Singh SK, Jeansson M, Quaggin SE. Curr Opin Nephrol Hypertens. 2011 May;20(3):258-62. doi: 10.1097/MNH.0b013e32834583ec. PMID: 21455064 Review.
- Insulin signaling to the glomerular podocyte is critical for normal kidney function.
Welsh GI, Hale LJ, Eremina V, Jeansson M, Maezawa Y, Lennon R, Pons DA, Owen RJ, Satchell SC, Miles MJ, Caunt CJ, McArdle CA, Pavenstädt H, Tavaré JM, Herzenberg AM, Kahn CR, Mathieson PW, Quaggin SE, Saleem MA, Coward RJM. Cell Metab. 2010 Oct 6;12(4):329-340. doi: 10.1016/j.cmet.2010.08.015. PMID: 20889126
- Glomerular filtration barrier.
Haraldsson B, Jeansson M.Curr Opin Nephrol Hypertens. 2009 Jul;18(4):331-5. doi: 10.1097/MNH.0b013e32832c9dba. PMID: 19458528 Review.
- Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis. Crowley SD, Vasievich MP, Ruiz P, Gould SK, Parsons KK, Pazmino AK, Facemire C, Chen BJ, Kim HS, Tran TT, Pisetsky DS, Barisoni L, Prieto-Carrasquero MC, Jeansson M, Foster MH, Coffman TM. J Clin Invest. 2009 Apr;119(4):943-53. doi: 10.1172/JCI34862. PMID: 19287096
- Adriamycin alters glomerular endothelium to induce proteinuria.
Jeansson M, Björck K, Tenstad O, Haraldsson B. J Am Soc Nephrol. 2009 Jan;20(1):114-22. doi: 10.1681/ASN.2007111205. Epub 2008 Dec 10. PMID: 19073829
- Functional and molecular alterations of the glomerular barrier in long-term diabetes in mice.
Jeansson M, Granqvist AB, Nyström JS, Haraldsson B. Diabetologia. 2006 Sep;49(9):2200-9. doi: 10.1007/s00125-006-0319-z. Epub 2006 Jul 26. PMID: 16868749
- Enhanced neuropeptide Y immunoreactivity and vasoconstriction in mesenteric small arteries from the early non-obese diabetic mouse.
Gradin KA, Zhu H, Jeansson M, Simonsen U.Eur J Pharmacol. 2006 Jun 13;539(3):184-91. doi: 10.1016/j.ejphar.2006.03.080. PMID: 16707122
- Morphological and functional evidence for an important role of the endothelial cell glycocalyx in the glomerular barrier.
Jeansson M, Haraldsson B. Am J Physiol Renal Physiol. 2006 Jan;290(1):F111-6. doi: 10.1152/ajprenal.00173.2005. PMID: 16091582
- Glomerular size and charge selectivity in the mouse after exposure to glucosaminoglycan-degrading enzymes.
Jeansson M, Haraldsson B.J Am Soc Nephrol. 2003 Jul;14(7):1756-65. doi: 10.1097/01.asn.0000072742.02714.6e. PMID: 12819235